Research progress of pyroptosis in pediatric surgical diseases
10.3760/cma.j.cn101070-20220815-00973
- VernacularTitle:细胞焦亡在小儿外科疾病中的研究进展
- Author:
Xiaohuan ZHAO
1
;
Zhu JIN
Author Information
1. 遵义医科大学附属医院小儿外科，遵义 563000
- Keywords:
Hirschsprung′s disease;
Biliary atresia;
Neonatal necrotizing enterocolitis;
Tumor;
Pyroptosis;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(1):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a kind of programmed cell death accompanied by inflammatory responses, which is mainly induced by the Caspase-1/4/5/11 activated mediated via inflammasomes or lipopolysaccharide.Pyroptosis causes the cleavage of various Gasdermin family members, including Gasdermin D, in which a large number of pro-inflammatory factors are released to cause inflammatory responses in various diseases.At present, pyroptosis has not been extensively analyzed in pediatric surgical diseases.This review summarizes the research progress of pyroptosis in pediatric surgical diseases like Hirschsprung′s disease, biliary atresia, neonatal necrotizing enterocolitis, and tumors.It is found that pyroptosis is involved in the occurrence and development of pediatric surgical diseases.The research on the specific mechanism of pyroptosis in pediatric surgical disease and involved signaling pathways contributes to the early diagnosis and treatment of some pediatric surgical diseases.
