Immunotherapy for fungal infections
10.3760/cma.j.cn101070-20230605-00447
- VernacularTitle:真菌感染的免疫治疗
- Author:
Yuan GOU
1
;
Yanling HU
;
Wenjian WANG
Author Information
1. 深圳市儿童医院呼吸科，深圳 518038
- Keywords:
Fungal infection;
Immunotherapy;
Cytokine therapy;
Cellular immunotherapy
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(1):20-25
- CountryChina
- Language:Chinese
-
Abstract:
Invasive fungal infections play an important factor threatening human health.In recent years, the number of the susceptible population of invasive fungal infections has increased rapidly, leading to a significant increase in the disease burden of human fungi.In 2022, the World Health Organization released a list of key fungal pathogens, aiming to promote global research and investment in fungal infection and antifungal resistance.At present, antifungal drugs are preferred for anti-fungal infection treatment, although the efficacy is limited by the adverse events and drug resistance.Improving the damaged host immune response is a reasonable way to improve the effectiveness of antifungal drugs.This article briefly described the epidemiology of fungal infections, summarized how hosts mediate the clearance of fungi by initiating innate and adaptive immune responses, and discussed the prospects and clinical evidence supporting immunomodulatory therapy for invasive fungal infections.
