Advances in neutrophil extracellular traps in systemic juvenile idiopathic arthritis
10.3760/cma.j.cn101070-20220614-00712
- VernacularTitle:中性粒细胞胞外陷阱在全身型幼年特发性关节炎中的研究进展
- Author:
Bin HU
1
;
Meiping LU
Author Information
1. 浙江大学医学院附属儿童医院风湿免疫过敏科，杭州 310003
- Keywords:
Neutrophils;
Neutrophil extracellular traps;
Systemic juvenile idiopathic arthritis
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(10):789-792
- CountryChina
- Language:Chinese
-
Abstract:
Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease characterized by recurrent unprovoked systemic inflammation, activation of the innate immune system, without the generation of autoantibodies or autoreactive antigen-specific T cells.Its pathogenesis is still unclear, and clinical diagnosis and treatment are challenging.Neutrophil extracellular traps (NETs) derived from the innate immune system are a novel neutrophil defense mechanism, and their role in sJIA has been increasingly concerned.In order to further research the pathogenesis of sJIA and to find better clinical diagnosis and treatment methods, this article reviews the involvement of neutrophils and NETs in sJIA, the pathogenesis, relevant biomarkers, potential therapeutic targets and drugs.
