Research progress of endothelial injury after hematopoietic stem cell transplantation in children

VernacularTitle:儿童造血干细胞移植后内皮损伤的研究进展
Author: Ang WEI ¹ ; Tianyou WANG ; Maoquan QIN
Author Information

1. 国家儿童医学中心，首都医科大学附属北京儿童医院血液病中心，儿童血液病与肿瘤分子分型北京市重点实验室，儿科学国家重点学科，儿科重大疾病研究教育部重点实验室，北京　100045
Keywords: Hematopoietic stem cell transplantation; Endothelial injury; Mechanism; Child
From: Chinese Journal of Applied Clinical Pediatrics 2023;38(10):785-789
CountryChina
Language:Chinese
Abstract: Hematopoietic stem cell transplantation (HSCT) in children may lead to endothelial cell activation, and the induction of procoagulant, proinflammatory, and proapoptotic mediators, resulting in endothelial cell dysfunction and injury, as well as life-threatening complications.An effective management of endothelial cell activation, injury, and dysfunction is important for improving outcomes after HSCT.This article reviews the recent advances in the epidemiological features, pathogenesis and treatment of veno-occlusive disease/sinusoidal obstruction syndrome and transplant-related thrombotic microangiopathy after HSCT.