Latest Research Progress of the Mechanism of Non-coding RNA in Chemoresistance of Hepatocellular Carcinoma

VernacularTitle:非编码RNA在肝癌化疗耐药中的作用机制最新研究进展
Author: Xin LEI ¹ ; Zhilan LI ; Lingpeng LU ; Xiudi JIANG
Author Information

1. 上海中医药大学附属第七人民医院医学检验科,上海 200137
Keywords: non-coding RNA; hepatocellular carcinoma; chemotherapy; resistance mechanism
From: Journal of Modern Laboratory Medicine 2024;39(2):198-204
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related death,following lung cancer,colorectal cancer and gastric cancer.Chemoresistance is currently the major challenge in clinical treatment of HCC patients,and it is also the primary cause of the poor prognosis and high recurrence rate of patients.There are multiple factors and complex mechanisms in the occurrence of HCC drug resistance.Recent research has shown that non-coding RNA(ncRNA)is closely related to HCC chemoresistance.By regulating the expression of target genes and protein translation,ncRNA affects the occurrence,metastasis,and prognosis of HCC and is expected to become a therapeutic biomarker and potential drug therapeutic target for HCC.Therefore,this study reviews several common ncRNAs,including long non-coding RNAs(LncRNAs),miRNAs and transferRNA(tRNAs),in the molecular mechanisms and research progress of HCC chemoresistance,providing new ideas for solving the problem of HCC chemoresistance.