Advances in the Mechanism of Phage Resistance to Bacterial Biofilms and Strategies for Its Application
10.3969/j.issn.1671-7414.2024.01.037
- VernacularTitle:噬菌体抗细菌生物膜机制及应用策略的研究进展
- Author:
Peini YANG
1
;
Qingrong LI
;
Jiang LI
;
Wei HE
;
Ping'an HE
;
Mei LÜ
;
Xu YANG
Author Information
1. 昆明医科大学第二附属医院检验科,昆明 650032
- Keywords:
phage;
bacterial biofilm;
bacteriophage anti-bacterial biofilm mechanism;
phage application
- From:
Journal of Modern Laboratory Medicine
2024;39(1):199-204
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial biofilms(BF)are complex microbial communities formed by bacteria on living or abiotic surfaces.Their formation significantly enhances bacterial virulence and drug resistance and is associated with a high proportion of chronic bacterial infections,posing a serious threat to human health.The ability of traditional antibiotics and commonly used disinfectants to clear biofilms is limited,and an effective new strategy to treat BF is urgently needed.Bacteriophage,as a kind of virus that can infect and lyse bacteria,has high safety and specificity,and is considered as a promising alternative method for the treatment of BF.In this paper,the mechanism of bacteriophage anti-bacterial biofilm and the application strategies based on bacteriophage and its derivatives in the prevention and control of bacteriophage biofilm formation were reviewed,which provided new ideas for the development of efficient bacteriophage anti-bacterial biofilm methods.
