Analysis of the Difference of Plasma Soluble Glycoprotein A Expression in Positive and Negative Anti-M and Anti-"Mia"Levels in Healthy Blood Donors
10.3969/j.issn.1671-7414.2024.01.022
- VernacularTitle:健康献血者血浆可溶性糖蛋白A(GPA)在抗-M与抗-"Mia"抗体阳性及阴性中表达差异的分析研究
- Author:
Yanlian LIANG
1
;
Linfeng WU
;
Xiongchi TANG
;
Yuqing SU
;
Fan WU
;
Shuang LIANG
;
Liyan SUN
Author Information
1. 深圳市血液中心输血医学研究所,广东深圳 518040
- Keywords:
glycoprotein A;
MN blood group;
anti-M antibody;
anti-"Mia"antibody
- From:
Journal of Modern Laboratory Medicine
2024;39(1):123-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the expression of soluble glycoprotein A(GPA)in plasma of healthy blood donors and anti-M and anti-"Mia"antibodies.Methods Plasma from healthy donors from February 9,2022 to February 15,2023 was collected:irregular antibody-negative NN type(group Ⅰ,n=118)and MM type(group Ⅱ,n=51),anti-M antibody positive NN type(group Ⅲ,n=145)and anti-"Mia"antibody positive companion type(group Ⅳ,n= 87),the GPA content in plasma of different individuals in 4 groups was detected,and the difference in GPA expression was analyzed by t-test.Results The average plasma GPA contents in groupsⅠ,Ⅱ,Ⅲ and Ⅳ were 9.941±0.252,10.97±0.256,5.139±0.129 and 4.28±0.139ng/ml,respectively.The average GPA content of groups Ⅰ and Ⅱ was higher,and the average GPA content of groups Ⅲ and Ⅳ was lower,and the differences were statistically significant(all P＜0.01).Conclusion The GPA content in plasma of healthy donors with anti-M and anti-"Mia"antibodies was significantly lower than that of the antibody-negative group.The results of this study lay a foundation for further investigation of whether GPA in plasma has the ability to neutralize anti-M and anti-"Mia"antibodies,improve disease diagnosis and safe blood transfusion.
