Research Progress of Henoch-Schonlein Purpura Experimental Animal Model Based on the Combination of Disease and Syndrome
- VernacularTitle:过敏性紫癜病证结合实验动物模型研究进展
- Author:
Qian ZHENG
1
;
Xianqing REN
Author Information
- Keywords: Henoch-Schonlein purpura; Animal model; Combination of disease and syndrome; Syndrome of stasis and heat
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(12):3955-3960
- CountryChina
- Language:Chinese
- Abstract: Henoch-Schonlein purpura(HSP)combination of disease and syndrome model has short modeling time,strong operability and high repeatability,which is more suitable for the research of TCM and integrated traditional Chinese and Western medicine.However,there are still the following deficiencies:①Lack of model evaluation criteria.What criteria should be used to establish successful animal models and whether the diagnostic criteria for human HSP are of reference significance?In the future,we should cooperate with Chinese veterinary medicine to carry out omics studies at various levels including genome,proteome and metabolome by combining the unique information of animals with the theories and methods of systems biology,and formulate the criteria for determining HSP animal models through data integration.In terms of syndrome:all the existing models are the model of animal stasis and heat syndrome caused by gavage of heat-induced drugs,but there is no criterion for the successful establishment of syndrome.In the future,it can be combined with ethanol,high-fat diet and fatty milk on the basis of simple heat-induced drug gavage,and compare different combination groups.In the aspect of syndrome evaluation,the four-diagnosis quantitative syndrome differentiation system was introduced to establish the TCM syndrome model evaluation scale of Henoch-Schonlein Purpura's stasis and heat.② There are great differences between animal model and clinical practice,and the reproducibility is low.At present,the combined models of disease and syndrome focus on purpura nephritis,and in the establishment of the animal model of pure dermal allergic purpura,the skin damage rate of the animal model(such as purpura,purpura)is low.In the future,we can learn from the modeling method of other allergic diseases,and increase the excitation times in the operation steps,in order to improve the skin damage rate.③All the existing HSP models are the syndrome model of blood stasis and heat first,and the disease model of HSP is reconstructed.However,the actual disease occurrence is the syndrome in the disease,and the syndrome is the pathological summary at a certain stage in the development of the disease,which is dynamic.In the future,the intervention operation of the etiology and syndrome should be carried out on experimental animals at the same time,so as to build a stable time window for the combination of disease and syndrome.
