Effects of Burdock Leaf Extract NBY-4 on Oxidative Damage of Vascular Endothelial Cells
- VernacularTitle:牛蒡叶化合物NBY-4对血管内皮细胞氧化损伤的影响
- Author:
Kaixia WANG
1
;
Jingjing YAN
;
Panxia CAO
;
Menghui HU
;
Liping DAI
;
Hong WU
Author Information
- Keywords: NBY-4; Oxidative damage; NF-κB; Endothelial cells
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(12):3899-3907
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the function of burdock leaf extract NBY-4 in protecting vascular endothelial cells from oxidative damage.Methods The oxidative damage model of vascular endothelial cells was established with hydrogen peroxide(H2O2).ROS,LDH,SOD,apoptosis rate and the expression of apoptosis were measured;Further test the nuclear transcription factor-κB(NF-κB).Results In the model group,H2O2 increased the apoptosis rate of endothelial cells,increased the ratio of Bax/Bcl-2 and the expression of Caspase-3,promoted the production of ROS and LDH in endothelial cells,and inhibited the level of SOD,resulting in oxidative damage to endothelial cells(P<0.05).NBY-4 could slow down the process of these effects;At the same time,NBY-4 can reduce NF-κB in endothelial cells.Conclusion NBY-4 can inhibit endothelial cell apoptosis and antioxidant damage by NF-κB signaling pathway.
