To Explore the Harmful Outcomes Induced by Traditional Chinese Medicine Based on the Mechanism of Programmed Cell Death and Inflammatory Response
- VernacularTitle:基于细胞程序性死亡机制及炎性反应探讨中药诱发的有害结局
- Author:
Ying LI
1
;
Baixuan SHEN
;
Wenxian LI
;
Jialin WANG
;
Yuanhui GUO
;
Chuanxin LIU
Author Information
- Keywords: Toxicity of Chinese medicine; Inflammatory reaction; Programmed cell death; Pyroptosis; Necroptosis; Ferroptosis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(12):3797-3807
- CountryChina
- Language:Chinese
- Abstract: Objective In this paper,the harmful effects and mechanisms induced by traditional Chinese medicine were expounded by combining the mechanism of programmed cell death and inflammatory reaction.It is expected to provide data support and theoretical reference for the rational use of traditional Chinese medicine and toxicology research.Methods By systematically analyzing the correlation between cell death and inflammatory response,the molecular mechanisms of pyroptosis,programmed cell necrosis and ferroptosis at home and abroad were summarized,and the harmful outcomes induced by traditional Chinese medicine were further discussed.Results Different toxic traditional Chinese medicines and their active ingredients have different tolerances to biological organisms.Programmed cell death is an important molecular mechanism for the toxicity of traditional Chinese medicines.Its signaling pathways are complex and diverse and are often accompanied by inflammatory reactions.Both of them have a certain effect on the toxic effects of traditional Chinese medicine.Conclusion Traditional Chinese medicine can provide inflammatory mediators for inflammatory response pathways through cell death or change the physiological balance of cells,thereby inducing inflammatory cascade reactions and promoting harmful outcomes in various systems of the body under the dual effects of cell death and inflammatory response.
