Polymorphisms in the SERPINA1 Gene and the Risk of Chronic Obstructive Pulmonary Disease in a Korean Population.
10.4046/trd.2008.65.4.285
- Author:
Seung Ick CHA
1
;
Jin Eun CHOI
;
Jong Myung LEE
;
Seung Soo YOO
;
Chang Ho KIM
;
Won Kee LEE
;
Tae Hoon JUNG
;
Nung Soo KIM
;
Jae Yong PARK
Author Information
1. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Original Article
- Keywords:
SERPINA1 gene;
Polymorphism;
COPD
- MeSH:
Alleles;
Case-Control Studies;
Genetic Predisposition to Disease;
Genotype;
Humans;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Pulmonary Disease, Chronic Obstructive;
Sample Size
- From:Tuberculosis and Respiratory Diseases
2008;65(4):285-291
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We conducted a case-control study to evaluate the potential association between SERPINA1 genotypes (M1Val, M1Ala, S, and Z) and the risk COPD. METHODS: The study population consisted of 93 patients with COPD and 112 healthy controls. The polymerase chain reaction and restriction fragment length polymorphism for detecting the SERPINA1 variants. RESULTS: The M2 allele of the SERPINA1 gene was significantly associated with the risk of COPD in Koreans. The effect of the M2 allele on the risk of COPD was more pronounced in the subgroup <64 years. CONCLUSION: These results suggest that SERPINA1 polymorphisms may contribute to a genetic predisposition for COPD. However, additional studies with larger sample sizes are required to confirm our findings.
