Research Status of Biosynthesis and Pharmacological Effects of Podophyllotoxin Drugss
- VernacularTitle:鬼臼毒素类药物的生物合成及药理作用的研究现状
- Author:
Yuanhui GUO
1
;
Baixuan SHEN
;
Shuang HAN
;
Jingjing LI
;
Jiajia DUAN
;
Chuanxin LIU
Author Information
- Keywords: Podophyllotoxin; Podophyllotoxin drugs; Artificial synthesis; Pharmacological effects; Toxicological effects; New dosage form of podophyllotoxin
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(12):3785-3796
- CountryChina
- Language:Chinese
- Abstract: Objective This paper summarizes the research progress of biosynthesis and pharmacological effects of podophyllotoxin drugs,in order to provide reference for the wide application of these drugs.Methods The plant source,chemical structure,action mechanism and synthesis pathway of podophyllotoxin drugs were summarized.The pharmacological and toxicological characteristics and mechanisms of these drugs were discussed,and the research progress of new dosage forms of podophyllotoxin drugs was reviewed.Results Podophyllotoxin and its derivatives are important chemical constituents in the plants of the podophyllum,such as Dysosma versipellis,Diphylleia sinensis,Sinopodophyllum hexandrum.This kind of drug has few natural sources and can be artificially produced through chemical and biosynthetic pathways.Podophyllotoxin drugs have pharmacological effects such as anti-inflammatory,anti-tumor and anti-virus,but their toxic effects need to be paid attention to.Drugs can be transported by carriers to reduce toxicity and increase effect.Conclusion Podophyllotoxin drugs have broad clinical application prospects,and will be further studied and applied in the fields of anti-inflammatory,anti-tumor and anti-virus in the future.
