Analysis of the Anastomosis between the Animal Model of Alopecia Areata and the Characteristics of Clinical Disease
10.11842/wst.20221123002
- VernacularTitle:斑秃动物模型与临床病证特点的吻合度分析
- Author:
Yuanxin ZHANG
1
;
Xue WANG
;
Lin GUO
;
Shuo NAN
;
Mingsan MIAO
Author Information
1. 河南中医药大学药学院 郑州 450046
- Keywords:
Alopecia areata;
Animal model;
Combination of disease and syndrome;
Clinical anastomosis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2023;25(11):3744-3750
- CountryChina
- Language:Chinese
-
Abstract:
In this study,the existing animal models of alopecia areata were systematically summarized based on literature review and disease and syndrome characteristics assignment method,and the clinical anastomosis was analyzed.The results showed that cell induction and skin transplantation had a high anastomosis with the clinic,and the anastomosis was as high as 80%.The anastomosis between imiquimod cream and cyclophosphamide induced alopecia areata was 72%.C3H/HeJ mice and C57BL/6 mice were selected as the first choice in terms of the pathogenesis of alopecia areata disease,pathogenic factors,replicability,convenience and practicability of the model.Other SCID mice,B6.KM-AA mice,SD rats and BALB/c mice can be selected appropriately according to the content and period of the experimental study of alopecia areata.It is found that the existing models of alopecia areata mainly rely on Western medicine,lack of pathogenic factors of traditional Chinese medicine,and the model of combining disease and syndrome of alopecia areata is not widely used in practice.Based on this,it is suggested that the animal model of"combination of disease and syndrome"should be considered in the subsequent construction of alopecia areata model to make it more suitable for clinical characteristics of disease and syndrome.We can add the relevant indicators of different syndrome types of liver and kidney insufficiency,blood stasis and maoqiao,blood deficiency and blood heat and other pathogenic factors,and add the apparent indicators of animal mental state,diet and water intake,behavior,etc.,to improve the animal model of alopecia areata which is highly consistent with the clinical characteristics of traditional Chinese and western medicine.
