Review in Treatment of Inflammatory Diseases with Flavonoids Based on NLRP3 Inflammasome
10.11842/wst.20221115001
- VernacularTitle:黄酮类成分防治NLRP3炎症小体过度激活引发的疾病的研究进展
- Author:
Xueyan ZHANG
1
;
Bisheng HUANG
;
Juan LI
Author Information
1. 湖北中医药大学药学院 武汉 430065
- Keywords:
NLRP3 inflammasome;
Flavonoids;
Mechanisms;
Diseases
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2023;25(11):3523-3532
- CountryChina
- Language:Chinese
-
Abstract:
NLRP3(NLR family pyrin domain containing 3)is the core of the inflammatory response,and its excessive activation involves the development of various diseases,including neurodegenerative diseases,autoimmune diseases and metabolic disorders,etc.In recent years,it has been found that natural flavonoids can extensively inhibit the diseases caused by NLRP3 inflammation overactivation via various mechanisms,including resistance to oxidative stress,promotion of autophagy,stabilization of mitochondrial function,adjustment ion channels and inhibition of NLRP3 inflammation composition.In this paper,we reviewed the relevant latest research reports,compiled the types and pathogenesis of diseases caused by excessive activation of NLRP3 inflammation,and summarized the mechanisms on the prevention and treatment of various diseases by inhibiting NLRP3 inflammation with natural flavonoids.This review provides new ideas for the development of new drugs using flavonoid components in the prevention and treatment of NLRP3 inflammatory-related diseases.
