Analysis of Animal Models of Ovarian Cancer Based on the Clinical Characteristics of Traditional Chinese and Western Medicine
10.11842/wst.20221030006
- VernacularTitle:基于中西医临床病症特点的卵巢癌动物模型分析
- Author:
Xinxin ZHOU
1
;
Qianqian LIU
;
Fangmian DU
;
Li BAI
;
Mingsan MIAO
Author Information
1. 河南中医药大学 郑州 450046
- Keywords:
Ovarian cancer;
Animal models;
Combination of pathologies;
Chinese and western medicine
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2023;25(10):3272-3278
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer is a heterogeneous malignant tumor,one of the most common causes of cancer death in women worldwide,and there is currently no effective treatment available for its treatment,which seriously affects women's life and health.In order to deeply explore the pathogenesis of ovarian cancer and study the specific therapeutic drugs and methods,this paper summarizes,summarizes,assigns and evaluates the clinical characteristics of traditional Chinese and Western medicine for ovarian cancer,and screens out a more complete animal model.Through CNKI,Wanfang,Pubmed and other databases,the relevant content of ovarian cancer animal models was collected and sorted,and the model diagnostic indicators were assigned and the consistency was evaluated.In the evaluation of the model,it is found that the animal model of spontaneous ovarian cancer can simulate the pathogenesis process of human natural ovarian cancer,and the model has high modulus rate,high similarity,and high consistency with the clinical characteristics of traditional Chinese and Western medicine.The subcutaneous tumor graft type model and the blood stasis type model were in good clinical agreement with traditional Chinese medicine,a high degree of similarity,and a longer survival time.At present,animal models of ovarian cancer are mainly based on Western medicine models,and research on animal models consistent with traditional Chinese medicine syndromes is rare.Therefore,the improvement direction of ovarian cancer animal models and the necessity of improving the evaluation system are proposed,so as to make the animal models of ovarian cancer more clinical,and provide a theoretical basis for the determination of the efficacy of traditional Chinese medicine and the discussion of pharmacological effects of ovarian cancer,and provide a theoretical basis for the subsequent research on the pathogenesis and treatment measures of ovarian cancer,in order to improve the model of combining ovarian cancer symptoms in line with the clinical characteristics of traditional Chinese medicine and Western medicine.
