Modeling Method and Evaluation of Animal models of Hypertensive
- VernacularTitle:高血压动物模型的造模方法与评价
- Author:
Mengyan DU
1
;
Wei WU
;
Weiying LI
;
Xiaoxi JIANG
;
Yan MENG
;
Guanlin YANG
;
Huiyong ZHANG
Author Information
- Keywords: Hypertension; Animal model; Model building; Model Evaluation; Application
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(10):3254-3263
- CountryChina
- Language:Chinese
- Abstract: Hypertension is one of the main factors leading to cardiovascular death.The number of cardiovascular patients were about 330 million in China,and 245 million among them were suffering from hypertensive in 2021.The rates of treatment and control of hypertension were less than 45.8%from 1991 to 2018.Therefore,it is of great clinical significance and social value to carry out hypertension related research.Animal models of hypertension are important tools to explore the pathogenesis of hypertension and evaluate the development of antihypertensive agents.At present,there are many ways to establish animal models of hypertension,by consulting and sorting out the relevant papers of animal models of hypertension at home and abroad,the author summarized and discussed the replication methods,principles,features and applications of commonly used animal models from four aspects,such as genetics,surgical induction,environmental induction and pharmaceuticals induction,in order to provide a reference for the selection and establishment of more scientific animal models of hypertension and lay the foundation for the combined treatment of hypertension with Chinese and Western medicine.
