Progress of Research on the Cause of Tobacco Smoke is Based on the Discussion of the Endogenous Mechanism other than"Tobacco Poisoning"
10.11842/wst.20221211005
- VernacularTitle:基于烟草烟雾致病研究进展刍议"烟毒"之外内因机
- Author:
Danjun SONG
1
;
Pin LI
;
Jiapeng LENG
;
Lijian PANG
;
Ningzi ZANG
;
Xiaodong LYU
Author Information
1. 辽宁中医药大学 沈阳 110847
- Keywords:
Tobacco toxicity;
Tobacco smoke;
External toxicity;
Internal toxicity;
Research progress
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2023;25(10):3193-3200
- CountryChina
- Language:Chinese
-
Abstract:
In the past decades,numerous chemical analysis studies have identified numerous compounds in tobacco smoke,and the number is increasing,as of 2013,9582 compounds have been identified in tobacco smoke,including nicotine,tobacco smoke-specific nitrosamines,benzo[alpha]pyrene and other substances,as well as cotinine,4-(methylnitrosamine)-1-(3-pyridyl)-1-butanol and other products that are metabolized in the body.The products of metabolic transformation,such as cotinine and 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanol,can target the heart,lungs and other organs,inducing chronic obstructive pulmonary disease,coronary heart disease,lung cancer,esophageal cancer and other types of cancer.Chinese medicine's understanding of"toxicity"originates from the Nei Jing,which believes that"poisonous evil"can be an external pathogenic factor,but can also cause the five organs to lose harmony and produce phlegm and stagnation and other pathological products that accumulate into internal toxicity.The modern medical understanding of tobacco smoke toxic substances and their metabolites is quite consistent with the understanding of"external toxicity"and"internal toxicity"in Chinese medicine,so the author intends to explore the main components and pathogenic mechanisms of tobacco smoke harmful substances and their metabolites.To clarify the etiological characteristics and pathogenic transformation characteristics of"internal"and"external"tobacco smoke toxicity,so as to explore the modernization of"tobacco smoke toxicity"and the combination of tobacco smoke pathogenesis and TCM theory for TCM.Theoretical foundation is laid.
