Identification of Quantized Characterization of Liver Meridian Based on Raman Spectrum of Chinese Medicinal Materials
- VernacularTitle:基于拉曼光谱的中药归肝经辨识方法研究
- Author:
Shuming LIU
1
;
Hao LIANG
;
Ziwei ZHAO
;
Hui WANG
;
Yun WANG
Author Information
- Keywords: Traditional Chinese Medicine(TCM); Raman spectroscopy; Medicinal properties; Liver meridian; Artificial neural network; Identification model; Quantized characterization
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(9):3146-3152
- CountryChina
- Language:Chinese
- Abstract: Objective Based on the comparison and analysis of Raman spectra of liver meridian(including other meridian)and non-liver meridian(other meridian excluding liver meridian)traditional Chinese medicine,the accurate quantitative characterization data of liver meridian was obtained,and the liver meridian identification model was established and analyzed.Methods Taking 120 non-liver meridian(other meridian excluding liver meridian)traditional Chinese medicines(TCMs)as blank control and 120 liver-meridian(including other meridian)TCMs as experimental medicines,Raman spectra of 240 TCMs were obtained after sample pretreatment and Raman spectroscopy detection,and then quantified in units of 1 cm-1.Then combined with Random Forest(Random Forest,RF),Artificial Neural Network(Artificial Neural Network,ANN)and other algorithms,we constructed the identification models of quantized characterization of liver meridian.Results Compared with non-liver meridian(other meridian excluding liver meridian)TCMs,the Raman spectra of the liver meridian TCM were generally lower in the whole detection range,especially in the range of 200-1100 cm-1.The quantized Raman spectrogram data combined with ANN presented the best discrimination results with accuracy,precision>0.871,the receiver operating characteristic curve(ROC)was drawn and the area under ROC curve(AUC)was obtained,with AUC>0.921.Conclusion The Raman spectrogram of TCMs has significant correlation with liver meridian,which can be used as a whole quantized characterization of liver meridian.Combined with ANN,Raman spectrogram can carry out identification analysis efficiently and accurately,which is conducive to solving the bottleneck problem of lacking accurate data on medicinal properties and enriching the scientific connotation of attributing meridians.
