Progress in the BOLD-fMRI Brain Effect of Acupuncture Intervention in Alzheimer's Disease
- VernacularTitle:针刺干预阿尔茨海默病的BOLD-fMRI脑效应研究进展
- Author:
Delin REN
1
;
Yuting WEI
;
Mingli SU
;
Tiantian ZHU
;
Xingke YAN
Author Information
- Keywords: Acupuncture; Alzheimer's disease; Brain effect; Blood oxygen level-dependent functional magnetic resonance imaging
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(9):3098-3104
- CountryChina
- Language:Chinese
- Abstract: Alzheimer' disease(AD)is a neurodegenerative disorder characterized by memory impairment and multiple cognitive deterioration.Acupuncture intervention in AD has potential efficacy,but the mechanism of onset is not clear.Blood oxygen level-dependent functional magnetic resonance imaging(BOLD-fMRI)has the unique advantages of accurately locating abnormal AD brain areas and monitoring and analyzing functional activities,providing technical support for the study of AD brain effects.It have found that abnormal changes in functional activity in response to brain regions and brain networks are closely related to the development of AD.Previous studies have shown that acupuncture can exert therapeutic effects by improving the functional impairment of multiple cognitive-related brain regions and brain networks in AD,which may be the mechanism of brain function in AD.Based on BOLD-fMRI technology,this paper elaborates on three aspects:commonly used data analysis methods of AD,the brain function mechanism of AD pathogenesis,and the brain effect study of acupuncture intervention in AD.In order to provide a reference for further exploring the brain effect of acupuncture intervention in AD.
