A Data Mining-Based Study on the Medication Rules of Chinese Medicine to Treat Heart Failure with Diuretic Resistance
- VernacularTitle:基于数据挖掘的中药治疗心力衰竭伴利尿剂抵抗用药规律研究
- Author:
Hongxin GUO
1
,
2
;
Bin LI
;
Haifeng YAN
;
Xingyuan LI
;
Mingjun ZHU
Author Information
- Keywords: Chinese medicine; Heart failure; Diuretic resistance; Data mining; Medication rules; Zhenwu decoction
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(9):3063-3070
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the medication rules of clinical prescriptions of Chinese medicine in the treatment of heart failure with diuretic resistance based on data mining method.Methods Seven domestic and foreign databases,including CNKI and Wanfang,were searched for literature on Chinese medicine for heart failure with diuretic resistance from the establishment of the database to October 2021.Frequency analysis,association rule analysis and cluster analysis were used for statistical analysis.Results A total of 41 literatures were included,including 39 prescriptions.Yang deficiency and water retention were the main symptoms of the disease.A total of 72 single herbs were used,with a total of 438 times of use.There are 30 Chinese medicines with a frequency of more than 5 times,involving 9 efficacy categories,mainly tonic medicines,diuresis and dampness medicines,blood-activating and stasis-removing medicines,and interior-warming medicines.The association rule analysis yielded drug compatibility with Poria as the core,such as Atractylodis Macrocephalae Rhizoma→Poria and Cinnamomi Ramulus→Poria.Cluster analysis yielded six new formula combinations with efficacy in warming Yang,inducing diuresis,benefiting qi and invigorating Blood.Conclusion Heart failure with diuretic resistance is a syndrome of root vacuity and tip repletion,cold-heat complex,and the core pathogenesis is"deficiency","water"and"stasis".The treatment of this disease occurs by warming yang and excreting water,supplemented by replenishing qi and activating blood circulation.Poria with Atractylodis Macrocephalae Rhizoma and Cinnamomi Ramulus are commonly used combinations,and Zhen Wu Decoction is the basic formula for the treatment of this disease.
