Exploring the Theoretical Basis of Qi-Shi-Sheng-Jiang-Gui-Yuan Decoction in Treating GERD Based on the Correlation Between"Regulating Pivot with Pivot"and ICC Mitophagy
10.11842/wst.20220615007
- VernacularTitle:基于"以枢调枢"与ICC线粒体自噬相关性探讨芪石升降归元饮治疗GERD的理论基础
- Author:
Zhenyi LUO
1
;
Yu ZHANG
;
Huaying MENG
;
Yunyan ZHANG
;
Liqun LI
;
Lijian LIU
;
Jinjing TAN
;
Sheng XIE
Author Information
1. 广西中医药大学研究生院 南宁 530001
- Keywords:
Gastroesophageal reflux disease;
Regulating pivot with pivot;
Interstitial cells of Cajal;
Mitophagy;
Qi-shi-sheng-jiang-gui-yuan decoction
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2023;25(9):2989-2995
- CountryChina
- Language:Chinese
-
Abstract:
The Gastroesophageal reflux disease(GERD)is related to the dynamic disorder of the digestive tract caused by the imbalance of the viscera and meridians.The spleen and stomach are the hub of the qi machinery,transforming the essence of water and valley into energy and regulating the Yin and Yang of all bodies.The sympathetic balance between Ren-Du and Qi is the motivity of the spleen and stomach.Interstitial cells of Cajal(ICC)are the hub of digestive motility,which can maintain mitochondrial energy metabolism through mitochondrial autophagy and improve the digestive motility.Therefore,in this paper,the molecular biological basis of GERD was discussed based on the"regulating pivot with pivot"theory that the pivots of viscera and meridians drive ICC mitochondrial energy balance.It also explains the feasibility of Qi-Shi-Sheng-Jiang-Gui-Yuan Decoction in treating GERD based on"regulating pivot with pivot",which is helpful to realize the microscopization and concretization of"regulating pivot with pivot"theory and realize the modernization of TCM theory.
