Research Progress of Sweet Taste Receptors in the Pathogenesis of Type 2 Diabetes Mellitus and the Effect of Traditional Chinese Medicine
- VernacularTitle:甜味觉受体在2型糖尿病发病及中医药作用研究进展
- Author:
Tiefeng SUN
1
;
Libin ZHAN
;
Ningzi ZANG
;
Tianyi HANG
;
Lianlian ZHU
Author Information
- Keywords: Sweet taste receptor; Type 2 diabetes mellutis; Spleen is sweet; Research progress
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(8):2660-2667
- CountryChina
- Language:Chinese
- Abstract: Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disease characterized by disorders of insulin and glucose.As a disease closely related to our daily diet,the molecular mechanism of its pathogenesis is still unclear.Sweet taste receptors are a kind of G protein-coupled receptors with 7 times transmembrane.Although the research on the pathogenesis of T2DM has been gradually deepened,there are few studies on the mechanism of sweet taste damage in the state of disease.Therefore,in-depth study of the pathological mechanism of T2DM sweet taste receptor damage is of great significance to further understand the molecular characteristics of sweet taste receptors and explore new targets of traditional Chinese medicine in the treatment of T2DM.In this paper,the biological characteristics of sweet taste receptors,signal transduction mechanism of sweet taste receptors,sweet taste receptors and T2DM,sweet taste receptors and"spleen is sweet"are reviewed in order to provide the latest opinions for the targeted prevention and treatment of this kind of diseases by traditional Chinese medicine and the elucidation of related pathological mechanism.
