Regulatory Effects of Acupuncture on Gut Microbiota in Mice with Breast Cancer Related Fatigue
- VernacularTitle:针刺对乳腺癌癌因性疲乏模型小鼠肠道菌群的调节作用
- Author:
Zhuan LYU
1
,
2
;
Ruidong LIU
;
Kaiqi SU
;
Xiaodi RUAN
;
Shikui QI
;
Mingyue YU
;
Yiming GU
;
Jing GAO
;
Qi LIU
;
Lu FANG
;
Xiaodong FENG
Author Information
- Keywords: Cancer-related fatigue; Breast cancer; Acupuncture; Gut microbiota; 16S; rDNA
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(7):2402-2411
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of acupuncture on fatigue improvement and gut microbiota in mice with cancer-related fatigue(CRF),and explore its possible mechanism of action.Methods The mice model of CRF of breast cancer after chemotherapy was established by tumor bearing and chemotherapy.After acupuncture intervention,fatigue was evaluated by general condition,forced swimming and open field experiment.Then 16S rDNA sequencing was used to analyze the structural abundance of gut microbiota in mice.Results Acupuncture could significantly improve the fatigue degree and general condition of the mice model of CRF of breast cancer after chemotherapy.At the same time,acupuncture could adjust the abundance of gut microbiota structure,up-regulate the abundance levels of Lactobacillus,Bacteroides,firmicutes,actinobacteria,and down-regulate the abundance levels of Proteobacteria and Staphylococcus.There were also differences in the abundance of flora structure among the groups,but the abundance of beneficial bacteria was relatively high in the acupuncture group,and the abundance of pathogenic bacteria was relatively high in the other two groups.Conclusion Acupuncture may play a role in the treatment of CRF by regulating the abundance of gut microbiota structure,increasing intestinal beneficial bacteria,inhibiting pathogenic bacteria,improving body immunity,and alleviating adverse reactions caused by chemotherapy for breast cancer.
