Classification and Characteristics of Common Syndromes of Primary Liver Cancer Based on Hidden Structure and Factor Analysis
- VernacularTitle:基于隐结构和因子分析的原发性肝癌常见证候分类及特征研究
- Author:
Rongrong ZHANG
1
;
Mingyi SHAO
;
Yu FU
;
Ruixia ZHAO
;
Jingwen WANG
;
Man LI
;
Yunxia ZHAO
;
Fanlei SHAO
Author Information
- Keywords: Primary liver cancer; Hidden structure model; Factor analysis; Hierarchical cluster analysis; Syndrome
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(7):2344-2352
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the classification and characteristics of common syndromes of primary liver cancer and provide reference for clinical treatment.Methods Collect the four diagnostic information of patients with primary liver cancer from two top three TCM hospitals in Henan Province,and build a database.Using Lantern 5.0 software,based on two-step hidden tree analysis,a hidden structure model was constructed,and common syndromes of primary liver cancer were extracted through comprehensive clustering.SPSS 23.0 software was used for factor analysis and systematic cluster analysis to infer the potential syndromes.Combined with the results of different methods and professional knowledge,the syndrome classification of primary liver cancer was determined.Results A total of 1353 patients with 105 symptoms of primary liver cancer were included.59 symptoms with an analysis frequency≥40 were included to construct a hidden structure model,24 hidden variables were obtained,and 5 common syndromes were obtained by comprehensive clustering,namely,qi deficiency syndrome,liver depression and qi stagnation syndrome,blood stasis syndrome,water dampness stagnation syndrome,liver and gallbladder damp heat syndrome.20 common factors were obtained by factor analysis for symptoms with frequency>3%,and 8 common syndromes were inferred by cluster analysis with common factors.7 common syndromes and characteristics were finally determined by combining different methods and expertise.Conclusion The common syndromes of primary liver cancer are qi deficiency syndrome,liver depression and qi stagnation syndrome,blood stasis syndrome,water dampness stagnation syndrome,yin deficiency syndrome,liver and gallbladder damp heat syndrome,spleen deficiency and dampness stagnation syndrome.The results objectively reflect the actual situation of patients with primary liver cancer,and can provide reference for the treatment of primary liver cancer based on syndrome differentiation.
