Preparation and Evaluation of Compound Nanxing Pain Relief Gel
- VernacularTitle:复方南星止痛凝胶的制备及评价
- Author:
Xuezhong SONG
1
,
2
,
3
;
Lijing ZENG
;
Ming YAN
;
Yuan JI
;
Chenfeng ZHANG
;
Xin ZHANG
;
Tuanjie WANG
;
Wei XIAO
;
Zhenzhong WANG
Author Information
- Keywords: Compound Nanxing pain relief gel; Box-Behnken effect surface method; Prescription optimization; Quality evaluation; Active cutaneous anaphylaxis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(7):2256-2265
- CountryChina
- Language:Chinese
- Abstract: Objective To prepare Compound Nanxing Pain Relief Gel(CNPRG)and evaluate its quality and sensitization.Methods CNPRG uses Carbopol 980 NF as the matrix;Appearance,viscosity,coating,centrifugal stability,cold stability,thermal stability as comprehensive indicators,single test and Box-Behnken effector method to optimize the prescription;The quality evaluation methods of appearance,pH,viscosity,stability,vapor phase identification of volatile components,and determination of diaconitine and eugenol content of CNPRG were preliminarily established;CNPRG sensitization was assessed by Active Cutaneous Anaphylaxis.Results The best prescription for CNPRG was Carbopol 980 NF 0.35 g,drug 1.02 g,glycerol 5.00 g,and pH 6.20.CNPRG ′s appearance likes jelly,is smooth,uniform and delicate;pH=6.20±0.03;viscosity 68.43±1.14 Pa·s;Centrifugation,high,low temperature stability,no stratification and precipitation;Identify camphor,(±)-Borneol and(±)-Isoborneol,Cinnamaldehyde,eugenol,phenol;Hypaconitine content 0.2983±0.0073 μg·g-1;Eugenol content 155.66±0.97 μg·g-1;CNPRG confirmed no sensitization.Conclusion CNPRG has good appearance,stable quality and no sensitization,and it can provide a choice for the development of new dosage forms of compound Nanxing pain relief cream to alleviate sensitization.
