Study on a Core Outcome Set(COS)of Myasthenia Gravis in Clinical Trials of Chinese Medicine
10.11842/wst.20220526004
- VernacularTitle:中医药治疗重症肌无力临床研究核心结局指标集构建研究
- Author:
Xinchen JI
1
;
Baitong WANG
;
Peng XU
;
Dongmei ZHANG
;
Qiaoying LI
;
Tianying CHANG
;
Zhiguo LÜ
;
Jian WANG
Author Information
1. 长春中医药大学 长春 130117
- Keywords:
Myasthenia gravis;
Outcome indicators;
Traditional chinese medicine;
Core outcome set
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2023;25(6):2180-2187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To standardize the selection of clinical research outcome indicators,which can objectively evaluate the clinical efficacy or effect of traditional Chinese medicine in the treatment of myasthenia gravis.This study aims to standardize the construction of the core outcome set of clinical research of traditional Chinese medicine in the treatment of myasthenia gravis.Methods We followed the core outcome set development specification(COS-STAD)to carry out research,established a research working group,which set up a Delphi-method advisory group.Two graduate students of working group conducted a document research and meetings of patients to establishe an outcome set item pool of myasthenia gravis in clinical trials of Chinese medicine under the instruction of other members.With the questionnaire based on the content of item pool,we then carried out Delphi-method expert consultations and a consensus meeting.Results The core outcome set of clinical research on myasthenia gravis treated with traditional Chinese medicine included five outcome domains:endpoint outcome,myasthenia gravis symptom evaluation,medication evaluation,quality of life evaluation and safety outcome;Nine outcome measures:recurrence rate,incidence of hormone complications,incidence of crisis,QMGS scale(MGFA quantitative myasthenia gravis score),daily activity scale of MG patients(ADL),analysis of immunosuppressant dosage,analysis of glucocorticoid dosage,analysis of cholinesterase inhibitor dosage,and incidence of adverse events.Conclusion The five outcome domains and nine outcome measures included in the core outcome set can be used as outcome options for the efficacy evaluation of myasthenia gravis clinical research.
