Establishment controlled motor cortex impact injury model of rats and detection of motor dysfunction

VernacularTitle:可控性运动皮质撞击损伤大鼠模型的制备与运动功能障碍的检测
Author: Weilong SONG ¹ ; Guangzhi HAO ; Zhen WANG ; Hai JIN
Author Information

1. 中国人民解放军北部战区总医院神经外科,沈阳 110016
Keywords: traumatic brain injury(TBI); controlled cortical impact model(CCI); neuron specific enolase(NSE); sticker removal test; food pellets grasping test; rat
From: Chinese Journal of Neuroanatomy 2023;39(6):705-708
CountryChina
Language:Chinese
Abstract: Objective:This study was to establish a rat model of controlled motor cortex impact injury(CCI).Methods:SD rat CCI model was prepared by electromagnetic shock method.A neurologic severity score(NSS)was employed to evaluate the status of the rat after injury.The changes of neuron-specific enolase(NSE)in serum were detected by ELISA.The sensomotor function was detected by sticker removal test,and the fine motor function was de-tected by food pellets grasping test.Results:The serum NSE level of rats increased 1 h after CCI trauma,and reached the highest level 6 h after CCI trauma.The sensomotor function and fine motor function of CCI model rats were signifi-cantly impaired.Conclusion:The CCI model of rat motor cortex was successfully established,and the rats showed obvious motor dysfunction.