Immune checkpoint inhibitor related tuberculosis:a case report and literature analysis
10.3969/j.issn.1672-8467.2024.02.020
- VernacularTitle:免疫检查点抑制剂相关结核病:1例报道及文献分析
- Author:
Wen-Ting JIN
1
;
Jia-Yi NI
;
Bi-Jie HU
;
Jue PAN
Author Information
1. 复旦大学附属中山医院感染病科 上海 200032
- Keywords:
tumor;
immunotherapy;
immune checkpoint inhibitor(ICI);
tuberculosis;
PD-1;
PD-L1
- From:
Fudan University Journal of Medical Sciences
2024;51(2):272-276
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing application of immune checkpoint inhibitors(ICI)in anti-tumor therapy,ICI related infections are often neglected.Mycobacterium tuberculosis(MTB)is also a common pathogen.We reported a case of ICI related pulmonary tuberculosis from Zhongshan Hospital,Fudan University.Meanwhile,18 cases of ICI related tuberculosis infection were collected through literature search,and the characteristics of ICI related tuberculosis were analyzed to improve the understanding in clinic practice.All the cases were confirmed TB including 15 cases of pulmonary tuberculosis(1 case with complication of intestinal tuberculosis)and 4 cases of extra-pulmonary tuberculosis(1 case of disseminated tuberculosis,bone tuberculosis,tuberculous pericarditis and tuberculous pleurisy,respectively).The chest CT characteristics of pulmonary tuberculosis mainly included centrilobular nodules,ground glass nodules,empty lesions,patchy shadows,consolidation and large infiltration.Eighteen cases started anti-tuberculosis treatment,while 4 cases continued ICI treatment.Three cases suspended ICI(2 cases had remission after reuse)and 11 cases stopped ICI,and 1 case was not mentioned.ICI related tuberculosis may be a direct complication of tumor immunotherapy.It is necessary to screen tuberculosis infection and exclude active tuberculosis before immunotherapy.If there are suspected symptoms such as fever,cough and sputum during ICI treatment,active tuberculosis should be taken into account.
