Application of dezocine in patient-controlled intravenous analgesia after laryngectomy:a prospective randomized controlled study
10.3969/j.issn.1672-8467.2024.02.014
- VernacularTitle:地佐辛在喉癌术后静脉自控镇痛中应用的前瞻性随机对照研究
- Author:
Wen-Jing YI
1
;
Li-Chun WAN
;
Yi-Ting PAN
;
Jie LI
Author Information
1. 复旦大学附属眼耳鼻喉科医院麻醉科 上海 200031
- Keywords:
dezocine;
sufentanil;
postoperative analgesia;
laryngectomy
- From:
Fudan University Journal of Medical Sciences
2024;51(2):238-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate different doses of the analgesic effects of dezocine comparing with sufentanil after laryngectomy.Methods A total of 129 patients who underwent elective partial laryngectomy from Feb 2022 to Jan 2023 were randomly assigned to dezocine 0.5 mg/kg group(group D1),dezocine 0.6 mg/kg group(group D2)and sufentanil 2 μg/kg group(group S).Twenty-four hours amount of drugs,the visual analogue scale(visual analogue scale,VAS)and 48 h total pressing times of PCA(patient-controlled intravenous analgesia,PCIA)were compared among the three groups at 6,12,24 and 48 h after operation,and the postoperative adverse reactions(nausea,vomiting,dizziness,urinary retention and respiratory depression)were recorded.Results There was no significant difference in 24 h amount of drugs among the three groups.The VAS score of group D1 was higher than that of group S at 6 h postoperatively(P＜0.05),but did not differ significantly among the three groups at 12,24 and 48 h.There was no significant differences in the number of compressions and postoperative adverse reactions among the three groups.Conclusion Compared with sufentanil,0.6 mg/kg dezocine can provide the same degree of analgesic effect.However,no advantage was found to reduce adverse reactions.
