Clinical observation of splenectomy with distal pancreatectomy during cytoreductive surgery in epithelial ovarian cancer
10.3969/j.issn.1672-8467.2024.01.007
- VernacularTitle:脾脏联合胰尾切除在上皮性卵巢癌肿瘤细胞减灭术中的临床观察
- Author:
Yi-Xuan LIU
1
;
Qian-Qian YAN
;
Yu-Lian CHEN
;
Ying ZHOU
;
Rong JIANG
Author Information
1. 复旦大学附属中山医院妇科肿瘤科 上海 200032
- Keywords:
epithelial ovarian cancer(EOC);
cytoreductive surgery;
distal pancreatectomy;
splenectomy
- From:
Fudan University Journal of Medical Sciences
2024;51(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of splenectomy with distal pancreatectomy during cytoreductive surgery in epithelial ovarian cancer(EOC).Methods A total of 17 patients from Zhongshan Hospital,Fudan University and the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)received splenectomy with distal pancreatectomy during cytoreductive surgery in EOC were recruited.Their clinicopathological characteristics,postoperative complications and survival situation were retrospective analyzed.Results Of the 17 patients,there were 13 primary cases and 4 recurrent cases.Eleven cases(64.7%)had preoperative imaging finding with metastatic lesions in the splenic hilum,among whom 6 cases had distal pancreas metastasis during the operation.The drainage was placed in the splenic fossa for the measurement of amylase levels in drain fluid and was removed after 8(3-12)days.There were 4 patients had postoperative pancreatic fistula(POPF)of grade A,3 patients had POPF of grade B and no POPF of grade C occurred.The 2 patients with POPF of grade B improved after percutaneous drainage,and the rest recovered with somatostatin,antibiotic drugs and medicines without perioperative mortality.The interval between surgery to chemotherapy was 17.5(13-37)days.The median follow-up time was 14(4-64)months and the median progression-free survival was 10(5-32)months.Conclusion Splenectomy with distal pancreatectomy as part of cytoreduction surgery in EOC is needed for optimal resection,and the complication of pancreatic fistula could be managed conservatively.
