The role of age and body mass index on cancer occurrence in a hypertensive population:a retrospective cohort study
10.3969/j.issn.1672-8467.2024.01.002
- VernacularTitle:高血压人群年龄及体重指数对癌症发病共同作用的回顾性队列研究
- Author:
Xin-Yue GUO
1
;
Jia-Huan PENG
;
Hui-Lin XU
;
Yong-Fu YU
;
Guo-You QIN
Author Information
1. 复旦大学公共卫生学院生物统计学教研室 上海 200032
- Keywords:
bivariate response model;
generalized additive Cox proportional hazard model;
hypertension;
cancer;
body mass index(BMI)
- From:
Fudan University Journal of Medical Sciences
2024;51(1):12-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the combined effect of body mass index(BMI)and age with cancer occurrence among a hypertensive population in Minhang District,Shanghai.Methods Participants of this study were 212 394 hypertensive patients without cancer in Minhang District,Shanghai,registered in the electronic health information system from 2007 to 2015.Age and BMI were included as smoothing functions in the generalized additive Cox proportional risk model.The bivariate response model was constructed to visualize results using surface plots and to comprehensively analyze the association of BMI and age with the risk of cancer occurrence.Results A total of 22 141 participants developed cancer by Dec 31,2018.The association between age and the risk of cancer incidence showed an overall linear trend while the association between BMI and the risk of cancer incidence showed an overall"U"shape.BMI at about 26 kg/m2 showed the lowest risk of cancer incidence.The risk of cancer occurrence increased with increasing age in people with different BMIs.The associations between BMI and the risk of cancer incidence were different at different age groups:there was no significant association between BMI and the risk of cancer incidence in the young people(20-44 years).While in the middle-aged and older people aged over 45 years,BMI was associated with the risk of cancer incidence in a"U"shape.The lowest risk of cancer incidence was around the BMI of 26 kg/m2.Conclusion BMI among the population with hypertension should be controlled in a reasonable range,especially in the middle-aged and older population,to prevent cancer occurrence.
