Research progress of neuromodulation in the treatment of Parkinson's disease
10.3969/j.issn.1674-8115.2024.02.012
- VernacularTitle:神经调控技术在帕金森病治疗中的应用研究进展
- Author:
Canfang HU
1
,
2
;
Chuanyu ZHONG
;
Li CAO
Author Information
1. 上海交通大学医学院附属第六人民医院神经内科,上海 200233
2. 上海市第六人民医院金山分院神经内科,上海 201599
- Keywords:
neuromodulation;
Parkinson's disease(PD);
deep brain stimulation(DBS);
transcranial magnetic stimulation(TMS);
transcranial direct current stimulation(tDCS);
transcranial focused ultrasound(tFUS)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2024;44(2):258-263
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a common degenerative neurological disorder,characterized by static tremor,bradykinesia,myotonia and postural abnormalities.Dopaminergic drugs are the main drugs in the treatment of PD,but long-term use will lead to drug efficacy loss,and even cause some adverse reactions such as dyskinesia and"on-off"phenomenon.Neuromodulation is a kind of biomedical engineering technology that can stimulate or inhibit the activity of brain neurons and regulate the changes of neuroplasticity by means of electric energy,magnetic field,ultrasound and other methods,so as to achieve treatment and improvement of diseases.In the non-drug treatment of PD,neuromodulation,as a new therapeutic means,has shown good efficacy,and has the advantages of small adverse reactions and easy tolerance.Based on this,this article reviews the research progress of several common neuromodulation in PD,including deep brain stimulation,transcranial magnetic stimulation,transcranial direct current stimulation and transcranial focused ultrasound.
