The regulatory mechanism and research status of deiodinating isozymes at the cellular level of thyroid hormone levels

VernacularTitle:脱碘同功酶在细胞层面的甲状腺激素水平调控机制与研究现状
Author: Xin HE ¹ ; Ying PENG ; Jing PENG ; Shiqi WANG ; Ruochuan CHENG
Author Information

1. 昆明医科大学，昆明　650500
Keywords: Thyroidectomy; Exogenous thyroid hormone supplementation; Thyroid hormone; Deiodinase
From: Chinese Journal of Endocrine Surgery 2024;18(1):138-140
CountryChina
Language:Chinese
Abstract: As color doppler ultrasound listed as the thyroid to regular physical examination project, the positive detection rate of benign and malignant thyroid diseases has increased year by year. The population of patients after thyroid surgery is getting larger and larger, however, the research on how to replace the absent thyroid with exogenous thyroid hormone is not perfect. As the switch of thyroid hormone activation and deactivation, deiodinase plays an important role in maintaining the internal environment of human body. The expression of these enzymes will change with the different needs of each organ in the individual. In the past, many authors have made a detailed description of deiodinase in basic medicine, but the principle of action in clinical aspects is relatively lacking. In this paper, the mechanism of deiodinase was reviewed through literature reading, to explore the basic principle of deiodinase in exogenous thyroid hormone supplementation after thyroid surgery.