Comparative analysis of the efficacy of different surgical approaches in sporadic medullary thyroid carcinoma
10.3760/cma.j.cn.115807-20231225-00201
- VernacularTitle:散发性甲状腺髓样癌不同手术方式疗效分析
- Author:
Mingyu YANG
1
;
Chengqiu SUI
;
Kunlin LI
;
Hongbo WANG
;
Hao CHI
;
Dongyuan LAN
;
Kecheng BAI
;
Daqi ZHANG
Author Information
1. 吉林大学中日联谊医院甲状腺外科 吉林省外科转化医学重点实验室 吉林省甲状腺疾病防治工程实验室，长春 130033
- Keywords:
Sporadic;
Medullary thyroid carcinoma;
Surgical approaches
- From:
Chinese Journal of Endocrine Surgery
2024;18(1):57-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and prognosis of different surgical approaches in sporadic medullary thyroid carcinoma.Methods:A retrospective analysis was conducted on 101 patients with sporadic medullary thyroid carcinoma (MTC) who underwent surgical treatment at the Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, from Feb. 2009 to Nov. 2023. The patients included 36 males and 75 females, with a male-to-female ratio of 1:2.1. The median age of the patients was 47 years old, with an age range of 21 to 72 years old. The study divided participants into two groups based on their surgical methods: an observation group (78 cases) and a control group (23 cases). The observation group received surgical methods in accordance with expert consensus, while the control group did not. The study compared the efficacy and prognosis of the two groups.Results:Statistical differences were found between the two groups in terms of stage II and III in TNM staging, intraoperative frozen pathological findings, number of lymph node resections in the central group, number of lymph node metastases in the central group, number of lymph node resections in the lateral cervical region, postoperative follow-up time, and five-year postoperative serum procalcitonin (Ctn) levels ( P<0.05) .Both groups of patients obtained a significant decrease in Ctn after surgical treatment. In the observation group, Ctn was at the remission level in 57 cases (73.1%), at the stable level in 13 cases (16.7%), and at the progression level in 8 cases (10.2%), while in the control group, Ctn was at the remission level in 20 cases (86.9%), at the progression level in 3 cases (13.1%), and there were no patients at the stable level after the operation.One patient (1.3 per cent) in the observation group had a recurrence after surgery; Two patients (8.7 per cent) in the control group had a recurrence. Conclusions:Standardised and thorough surgery can maximise the clearance of metastatic lymph nodes, effectively reduce the recurrence rate, achieve better efficacy, and improve the long-term prognosis of patients without increasing the risk of surgery and postoperative complications.
