Correlation analysis between tumor burden and biochemical indicators of parathyroid adenoma
10.3760/cma.j.cn.115807-20231227-00205
- VernacularTitle:甲状旁腺腺瘤负荷与生化指标间相关性分析
- Author:
Qingyuan ZHENG
1
;
An SONG
;
Tianqi CHEN
;
Sen YANG
;
Jinheng XIAO
;
Ya HU
;
Quan LIAO
Author Information
1. 中国医学科学院北京协和医学院 北京协和医院基本外科，北京 100730
- Keywords:
Parathyroid adenoma;
Tumor burden;
Biochemical parameters
- From:
Chinese Journal of Endocrine Surgery
2024;18(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the correlation of tumor volume and weight with biochemical parameters in patients with parathyroid adenoma (PA) .Methods:A prospective electronic database collected clinical data on 208 patients with PA treated for the first time by surgery at department of general surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.The relationship between biochemical parameters and tumor volume and weight was analyzed with Spearman’s correlation.Results:Tumor volume and weight were positively correlated with parathyroid hormone (PTH) ( r=0.33, P<0.001; r=0.39, P<0.001), calcium ( r=0.16, P=0.018; r=0.18, P=0.007) and alkaline phosphatase levels ( r=0.24, P<0.001; r=0.27, P<0.001), respectively. Clinical correlates affecting serum PTH were age, serum calcium and tumor weight ( F=30.325, P<0.001) . Conclusions:Tumor burden in patients with PA correlates with some laboratory biochemical parameters. Age and cystic lesions of the tumor may influence the actual serum PTH levels.
