Serum SFRP-4 and HSP60 levels in pregnant women with gestational diabetes mellitus and their predictive value for adverse pregnancy outcomes
10.3760/cma.j.cn.115807-20221025-00293
- VernacularTitle:妊娠期糖尿病孕妇血清SFRP-4、HSP60水平对不良妊娠结局的预测价值
- Author:
Junhong SUN
1
;
Fangfang ZHANG
;
Liyuan ZHANG
;
Leihua LI
Author Information
1. 濮阳市人民医院检验科，濮阳 457000
- Keywords:
Gestational diabetes mellitus;
Secreted frizzled-related protein-4;
Heat shock protein 60
- From:
Chinese Journal of Endocrine Surgery
2023;17(6):711-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serum levels of secreted frizzled-related protein-4 (SFRP-4) and heat shock protein 60 (HSP60) in pregnant women with gestational diabetes mellitus (GDM) and their predictive value for adverse pregnancy outcomes.Methods:A total of 123 pregnant women with GDM who were admitted from Jun. 2020 to Aug. 2022 were collected as the observation group, and 120 healthy pregnant women who underwent obstetric examination in our hospital were gathered as the control group. Serum SFRP-4 and HSP60 levels were detected by enzyme-linked immunosorbent assay (ELISA) , clinical data of selected persons were collected; Pearson method was used to analyze the correlation between serum SFRP-4 and HSP60 levels and glucose and lipid metabolism indexes; ROC curve was used to analyze the serum SFRP-4 and HSP60 in the diagnosis of adverse pregnancy outcomes in patients with GDM.Results:There were no obvious differences in age, pre-pregnancy BMI, gestational age, pregnancy times, and serum HDL-C or LDL-C between the control group and the GDM group ( P>0.05) . FBG, FINS, HbA1c, HOMA-IR, TG, and TC in GDM group were obviously higher than those in control group [ (6.41±0.73) vs (4.98±0.61) mmol/L, (12.35±2.33) vs (7.61±1.56) mIU/L, (9.34±1.26) vs (5.74±0.23) %, (3.42±0.55) vs (1.27±0.53) , (1.74±0.82) vs (1.21±0.23) mmol/L, (4.98±1.21) vs (4.57±1.13) mmol/L] ( P<0.05) . The levels of serum SFRP-4 and HSP60 in the GDM group were obviously higher than those in the control group [ (5.68±1.78) vs (3.26±0.95) ng/mL, (32.56±6.28) vs (18.42±3.24) ng/mL] ( P<0.05) ; Serum SFRP-4 and HSP60 in GDM patients were positively correlated with FBG, FINS, HbA1c, and HOMA-IR ( P<0.05) , but had nothing to do with TG, TC, HDL-C, and LDL-C ( P>0.05) . Compared with the good pregnancy outcome group, the serum SFRP-4 and HSP60 levels in the poor group were obviously increased [ (7.41±1.62) vs (4.75±1.55) ng/mL, (38.31±5.76) vs (29.47±5.41) ng/mL] ( P<0.05) . The AUC of serum SFRP-4 combined HSP60 to diagnose adverse pregnancy outcomes in GDM patients was 0.931, with a sensitivity of 86.05% and a specificity of 87.50%. The combined diagnostic performance was higher than that of the single test ( Z=2.070, P=0.038; Z=2.001, P=0.045) . Conclusions:The levels of serum SFRP-4 and HSP60 in GDM patients are increased, which are related to GDM pregnancy outcomes. The combination of the two has certain diagnostic value for adverse pregnancy outcomes in GDM patients.
