Curative effect analysis of PVP combined with Zoledronic acid in the treatment of postmenopausal osteoporotic vertebral fracture (with video)
10.3760/cma.j.cn.115807-20211019-00316
- VernacularTitle:椎体成形术联合唑来膦酸治疗绝经后骨质疏松性椎体骨折的疗效分析（附视频）
- Author:
Jingjing XIE
1
;
Peng TENG
;
Bo ZHANG
;
Xuan SONG
Author Information
1. 上海交通大学医学院附属新华医院崇明分院骨科，上海 202150
- Keywords:
Zoledronic acid;
Postmenopausal osteoporosis;
Vertebral compression fracture;
Bone metabolism
- From:
Chinese Journal of Endocrine Surgery
2023;17(5):564-567
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy of PVP combined with zoledronic acid in the treatment of postmenopausal osteoporotic vertebral fractures.Method:90 patients with postmenopausal osteoporotic vertebral fractures treated in our hospital from Jul. 2018 to Aug. 2020 were selected. According to different treatment methods, the patients were divided into observation group and control group. The patients in both groups were treated with PVP. The patients in the control group were given oral alendronate, calcitriol capsules and calcium, and the patients in the observation group were given zoledronic acid injection, calcitriol capsules and calcium were taken orally for 1 year. BMD of lumbar spine, femoral neck, greater trochanter and ward triangle, lumbar ODI index and VAS score, serum BGP and β-CTX, PINP levels and adverse reactions during treatment. Results:One year after operation, the lumbar ODI index and VAS score of the observation group were significantly lower than those of the control group ( P<0.05), and the BMD of lumbar spine, femoral neck, greater trochanter and ward triangle were higher than those of the control group ( P<0.05). The levels of serum BGP, β-CTX and PINP levels in the two groups were significantly higher than those in the control group ( P<0.05) . Conclusion:Zoledronic acid can significantly improve bone metabolism, accelerate bone formation, increase BMD, reduce low back pain and improve lumbar function in patients with osteoporotic vertebral compression fracture after PVP.
