Study on liver dysfunction induced by methimazole and propylthiouracil for the treatment of hyperthyroidism

VernacularTitle:甲巯咪唑和丙硫氧嘧啶治疗甲状腺功能亢进症致肝功能异常的临床研究
Author: Jiayue XU ¹ ; Na SU
Author Information

1. 四川大学华西医院药剂科，成都　610041
Keywords: Methimazole; Propylthiouracil; Liver dysfunction
From: Chinese Journal of Endocrine Surgery 2023;17(4):508-510
CountryChina
Language:Chinese
Abstract: Methimazole (MMI) and propylthiouracil (PTU) are the only clinical antithyroid drugs,with definite efficacy,but a high incidence of adverse reactions.The Food and Drug Administration (FDA) warns that PTU can cause fatal explosive hepatocyte necrosis, but other research evidence has shown that MMI is as common as PTU in causing acute hepatocyte damage.In this study, we reported that in 6631 patients, after eliminating confounding factors such as demographic characteristics, initial daily dose and combined medication, there was no statistically significant difference in the proportion of liver injury between the MMI group and the PTU group ( P=0.762), the influencing factors causing abnormal liver function by two drugs were also analyzed.