Effect of high expression of APP proteina on postoperative radiotherapy in patients with brain gliom
10.3760/cma.j.cn.115807-20221219-00378
- VernacularTitle:脑胶质瘤组织中APP蛋白高表达对术后放疗的影响
- Author:
Yanhui ZHANG
1
;
Lijun SUN
;
Heng ZHAO
Author Information
1. 济宁医学院附属医院肿瘤科，济宁 272000
- Keywords:
Brain glioma;
Amyloid precursor protein;
Radiotherapy
- From:
Chinese Journal of Endocrine Surgery
2023;17(4):490-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore and analyze the influence of amyloid precursor protein (APP) protein high expression in brain glioma tissue on postoperative radiotherapy.Methods:Retrospective analysis was performed on 96 patients with surgically resected glioma admitted to the Department of Oncology, Affiliated Hospital of Jining Medical College from Feb. 2020 to Feb. 2022. Clinicopathologic data such as gender, age, tumor location, number of lesions, surgical resection, overall tumor burden reduction rate, radiotherapy dose, maximum lesion diameter of preoperative KPS score and Ki-67 proliferation index were collected, and 96 brain glioma tissue samples were collected.According to the effect of postoperative radiotherapy, the patients were divided into a good radiotherapy effect group (54 cases) and a poor radiotherapy effect group (42 cases), and the number, location, size, pathological grade and other clinical data of the two groups were compared. The expression level of APP in low-grade glioma (52 cases) and high-grade glioma tissue (44 cases) was detected by Western blot method. The clinicopathologic data of patients in the group with good radiotherapy effect and the group with poor radiotherapy effect were analyzed by single factor to find out the influencing factors of postoperative radiotherapy for patients with glioma. Multivariate Logistic analysis was used to analyze the relationship between APP protein expression and postoperative radiotherapy for glioma.Results:Among the 96 brain glioma patients, 56 cases had high expression of APP protein, with high expression rate of 58.33%. The high expression rate of APP protein in high grade gliomas was higher than that in low grade gliomas ( χ2=6.924, P < 0.05). Evaluation results of postoperative radiotherapy for 96 glioma patients showed complete remission was in 21 cases (21.88%), partial remission in 33 cases (34.38%), stable in 26 cases (27.08%) and progressive in 16 cases (16.67%), with an objective remission rate of 56.25% (54/96). Univariate analysis showed that the proportion of high grade glioma, maximum lesion diameter ≥6 cm, Ki67 proliferation index ≥10% and high expression of APP protein in the poor radiotherapy effect group was higher than that in the good radiotherapy effect group ( χ2=6.959, 9.423, 24.282, 37.481, P < 0.05). Multivariate Logistic regression analysis showed that the pathological grade of high-grade glioma ( OR=2.838, 95% CI: 1.501-5.366) and high expression of APP protein ( OR=3.089, 95% CI: 1.364-6.996) were independent risk factors for the effect of postoperative radiotherapy in patients with glioma ( P < 0.05) . Conclusions:APP protein is highly expressed in glioma tissues, and its expression increases with the increase of the pathological grade of glioma. APP protein high expression is an independent risk factor affecting the adverse effect of postoperative radiotherapy in glioma patients.
