Prevention and treatment of anti-osteoporosis drugs related parathyroid hyperfunction or hyperparathyroidism
10.3760/cma.j.cn.115807-20230717-00006
- VernacularTitle:关注抗骨质疏松药相关甲状旁腺功能增强或亢进的防治
- Author:
Lingquan KONG
1
;
Liyuan MU
;
Kainan WU
Author Information
1. 重庆医科大学附属第一医院乳腺甲状腺外科，重庆 400016
- Keywords:
Osteoporosis;
Anti-osteoporosis drug;
Negative calcium balance;
Parathyroid hyperfunction or hyperparathyroidism;
Anti-osteoporosis drugs related parathyr
- From:
Chinese Journal of Endocrine Surgery
2023;17(4):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a common age-related disease which has become a severe public health problem in China. Anti-osteoporosis drug is important to treat osteoporosis, but some patients have poor efficacy after using anti-osteoporosis drugs, which may be associated with anti-osteoporosis drugs related parathyroid hyperfunction or hyperparathyroidism. As a emergency drug for hypercalcemia crisis, anti-osteoporosis drug can cause a significant decrease in serum calcium. With the current recommended doses of vitamin D and calcium supplementation, some patients presented with a decreased level of serum calcium and negative calcium balance after receiving anti-osteoporosis drugs, stimulating parathyroid hyperplasia and enlargement, leading to parathyroid hyperfunction or hyperparathyroidism. During the treatment of anti-osteoporosis drugs, sufficient vitamin D and calcium supplementation on the basis of closely monitoring of serum calcium, parathyroid hormone (PTH) and related bone metabolism indicators is beneficial to maintain the stability of serum calcium and PTH, preventing anti-osteoporosis drugs related parathyroid hyperfunction or hyperparathyroidism. Furthermore, it can efficiently prevent and treat bone loss, fractures, height shortening, hunchback, systemic musculoskeletal and joints pain, metastatic vascular calcification and calcinosis universalis, improve the efficacy of anti-osteoporosis drugs, reduce adverse reactions, comprehensively improve the prognosis of osteoporosis patients, and protect people’s health.
