Advance progress and future trend of the natural origin adjuvants for tumor vaccines
10.13431/j.cnki.immunol.j.20230131
- VernacularTitle:天然源性佐剂在肿瘤疫苗中的应用进展与未来发展趋势
- Author:
Shuzhen LI
1
;
Hui ZHU
;
Yimin JIA
;
Yan YE
;
Ting CHEN
;
Cun SUN
;
Wenxiu WANG
;
Jieping LI
;
Quanming ZOU
;
Hao ZENG
;
Hongwu SUN
Author Information
1. 276400 临沂,山东省沂水县疾病预防控制中心
- Keywords:
Tumor vaccine;
Vaccine adjuvant;
Polysaccharides;
Saponins;
Flavonoid;
Plantvirus particle
- From:
Immunological Journal
2023;39(12):1090-1095
- CountryChina
- Language:Chinese
-
Abstract:
Tumor has become the major reasons cause of death,and its vaccine has become the effective tracts of treatment and prevention by enhancing the immune response of patients.However,most vaccines which are recombination subunit protein antigens are poorly immunogenic and difficult to induce a robust immune response in patients with compromised immune systems,resulting in poor marketing approval.The core component of the vaccine adjuvant can greatly enhance the strength,speed and duration of the immune response,thus becoming the key to the development of an ideal tumor vaccine.Most tumor vaccines are combined with tradition adjuvant such as aluminum,MF59 and AS adjuvant,but their products and patents are monopolized by large foreign companies.We found that natural adjuvants have many unique advantages,such as good biocompatibility and biodegradability,promoting the maturation of dendritic cell and the secretion of immune cytokines,significantly enhancing the tumor vaccine immune response,etc.In this paper,the application and future development of natural polysaccharides,saponins,flavonoid and plant virus-like particles in cancer vaccines were reviewed,which may lay a solid foundation for the development of the original and innovative adjuvants with domestic independent intellectual property rights.
