Progresses in the role of HMGB1/RAGE axis in tumor inflammation and the research of its targeting drug papaverine
10.13431/j.cnki.immunol.j.20230119
- VernacularTitle:HMGB1/RAGE轴在肿瘤炎症中的作用及其治疗药物罂粟碱的研究进展
- Author:
Anqi FAN
1
;
Xuhuan TANG
;
Fang ZHENG
;
Chenchen WANG
;
Quan GONG
;
Lian LIU
;
Mengxiang GAO
Author Information
1. 434025荆州,长江大学生命科学学院
- Keywords:
HMGB1;
RAGE;
Tumor inflammation;
Papaverine
- From:
Immunological Journal
2023;39(10):916-920
- CountryChina
- Language:Chinese
-
Abstract:
HMGB1's role in tumors is complex and diverse,and it exerts its biological function by combining with different receptors.One of the receptors is called RAGE,which is localized to the cell membrane and binds to HMGB1 released outside the cell.The HMGB1/RAGE axis promotes tumor development,moreover,tumor development and its drug resistance are closely related to inflammation.This article mainly reviews the molecular mechanism of HMGB1/RAGE axis in pro-inflammatory and protumor effects in pancreatic,colorectal and liver cancers.We also summarize the research progress of papaverine and its derivatives for the treatment of HMGB1/RAGE axis in tumor inflammation,with aims of providing new ideas for exploring the molecular mechanism of action in tumor inflammation,and providing a new theoretical basis for the research of HMGB1/RAGE axis therapeutics.
