Application of WHO molecular classification in endometrial cancer(2020)and its clinicopathological significance
10.13315/j.cnki.cjcep.2024.03.011
- VernacularTitle:WHO(2020)女性生殖系统肿瘤分子分型在子宫内膜癌中的应用与临床意义
- Author:
Liyu CAO
1
,
2
;
Zhuangzhuang TIAN
;
Lili ZHU
;
Zhenzhen BAI
;
Cong ZHANG
Author Information
1. 安徽医科大学附属阜阳医院病理科,阜阳 236000
2. 安徽医科大学病理学教研室,合肥 230032
- Keywords:
endometrial neoplasm;
molecular classification;
mismatch repair;
immunohistochemistry;
polymerase chain reac-tion
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(3):279-284
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the application and clini-copathological significance of molecular classification in endome-trial cancer(EC)of WHO(2020)tumors of the female repro-ductive system.Methods Sixty-two EC patients were collected and categorized into four subgroups,namely POLE mutation type,mismatch repair deficient(MMRd)type,non-specific molecular spectrum(NMSP)type,and p53 mutation type,based on WHO molecular classification tested by PCR and im-munohistochemistry.The correlation among four molecular sub-groups and their clinicopathological features were analyzed.Re-sults The molecular classification was distributed as follows:3(4.8％)cases were POLE-mutated,15(24.2％)cases MMRd,36(58.1％)cases NSMP and 8(12.9％)cases p53 abnormal expression.There were no significant differences a-mong POLE-mutated and infiltration depth,grade,lymph vascu-lar space invasion and other pathological factors such as lymph node metastasis and FIGO stage(P＞0.05).Among 15 patients with MMRd,the proportion of FIGO stage Ⅱ+Ⅲ significantly increased.One case showed abnormal overexpression of p53 pro-tein,while two cases showed complete loss of expression in MMRd subgroup.36 cases of NSMP were associated with low histopathological grade(Grade Ⅰ+Ⅱ)(P＜0.05),and no significant differences were observed among NSMP and other clinicopathological factors(P＞0.05).The p53 abnormal ex-pression in 8 cases was related to high histopathological grade(Grade Ⅲ)(P＜0.05),and the rate of lymph node metastasis and FIGO stage Ⅱ+Ⅲ significantly increased in patients with p53 abnormal expression,and although the difference was not statistically significant(P＞0.05).Conclusion The molecu-lar subgroups of EC have certain clinical application value,the cases with MMRd and p53 abnormal expression may have poor prognosis than these with POLE-mutated and NSMP.
