Clinicopathological features of gastric fundus mucosal adenocarcinoma:report of four cases
10.13315/j.cnki.cjcep.2024.02.014
- VernacularTitle:胃底腺黏膜型腺癌4例临床病理特征
- Author:
Xiaoyu SUN
1
,
2
;
Xiaowei XUE
;
Weixun ZHOU
Author Information
1. 中国医学科学院北京协和医院病理科,北京 100730
2. 山东省淄博市中心医院病理科,淄博 255020
- Keywords:
gastric adenocarcinoma of fundic-gland mucosa type;
early gastric cancer;
biopsy pathology;
immunohistochem-istry
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(2):189-193
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the clinicopathological changes of gastric adenocarcinoma of fundic-gland mucosa type(GA-FGM).Methods The clinicopathological data of 4 cases of GA-FGM was analyzed retrospectively.The expression of MUC5AC and MUC6 was detected by immunohistochemical method,and review relevant literature.Results The tumor dif-ferentiated into gastric foveal epithelium and gastric fundus gland.The differentiated part of the pits consists of high colum-nar neoplastic epithelium with low atypia,which can be papilla-ry,villous or tubular morphology.Immunohistochemical staining showed MUC5AC expression.The gastric fundus gland differen-tiated into cervical mucous cells,main cells and parietal cells,and was positive for MUC6 immunohistochemistry.Conclusion Gastric adenocarcinoma of fundic-gland mucosa type has u-nique pathologic characteristics,which is very difficult to diag-nose in biopsy,and the morphology of GA-FGM overlaps with that of gastric fundus adenocarcinoma,so we need to strengthen our understanding.Immunohistochemistry plays an important role in differential diagnosis.
