High grade B cell lymphoma with concurrent MYC rearrangement and 11q aberrations:a clinicopathological analysis
10.13315/j.cnki.cjcep.2024.01.007
- VernacularTitle:伴有MYC基因重排和11q异常的高级别B细胞淋巴瘤的临床病理学分析
- Author:
Susu LU
1
;
Guannan WANG
;
Wugan ZHAO
;
Dandan ZHANG
;
Yanping ZHANG
;
Sixia HUANG
;
Enjie LIU
;
Weiwei WANG
;
Lan ZHANG
;
Wencai LI
Author Information
1. 郑州大学第一附属医院病理科,郑州 450052
- Keywords:
high grade B cell lymphoma;
MYC rearrangement;
11q aberrations
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(1):24-28
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features,molecular genetics and prognosis of high grade B cell lymphoma with concurrent MYC rearrangement and 11q aberra-tions(HGBCL-MYC-11q).MethodsThree cases of HGBCL-MYC-11q were reviewed and analyzed using hematoxylin-eosin staining,immunohistochemistry,EBER in situ hybridization and fluorescence in situ hybridization.Clinical data were collected with follow-up.Results All three patients were male,age was 10,61,and 74 years,respectively.All patients had Ann Arbor stage Ⅳ disease.All three cases were biopsies occurring in the nasopharynx,upper pharynx and ileocecus,respectively.Three cases were morphologically similar to diffuse infiltrative growth of tumor cells,moderate or moderately large cells,round to slightly irregular nuclei and easily visible mitotic figures.Focal necrosis was noted in one case.One case exhibited the distinct"starry sky"pattern.All cases expressed CD20,BCL6 and MUM1 and high Ki67 index,two cases expressed CD10 and two cases ex-pressed BCL2.CD3,CD30 and TDT were all negative.EBER in situ hybridization was all negative.FISH analyses using C-MYC break-apart probes were all positive and all cases had 11q aberrations.One case only had the 11q23.3 amplification;and one case only had the 11q24.3 loss.After a follow-up for 1-18 months,one patient died and two patients survived with disease.ConclusionHGBCL-MYC-11q is rare,morphologically similar to BL/HGBCL,with MYC rearrangement and 11q abnormali-ties.We should enhance awareness of the disease and improve more accurate diagnosis and differential diagnosis of the disease.
