Significance of INSM1 in pathological diagnosis of medullary thyroid carcinoma
10.13315/j.cnki.cjcep.2023.12.015
- VernacularTitle:INSM1在甲状腺髓样癌病理诊断中的意义
- Author:
Xuehan WANG
1
,
2
;
Yanjun ZHENG
;
Xiaoshuang WANG
;
Yan LIU
;
Yongping CAI
Author Information
1. 安徽医科大学基础医学院病理教研室,合肥 230032
2. 安徽医科大学附属宿州医院病理科,宿州 234000
- Keywords:
thyroid neoplasms;
medullary thyroid carcinoma;
INSM1;
differential diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2023;39(12):1487-1491
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of insulinoma associated protein 1(INSM1)in the pathological diagnosis and differential diagnosis of medullary thyroid carcinoma(MTC).Methods Twenty-eight cases of MTC were collected as the ex-perimental group and 25 cases of thyroid tumors(6 cases of transparent trabecular tumors,16 cases of poorly differentiated cancer,2 cases of spindle cell papillary carcinoma,and 1 case of thyroid paraganglioma)that needed to be differentiated from MTC in the same period were collected as the control group.The expression of INSM1 was detected using immunohistochemical EnVision method,and the sensitivity and specificity of INSM1 in MTC were analyzed,and compared with traditional MTC markers(Syn,CgA,CT,and CEA).Results The positive rate of IN-SM1 in the MTC group was96.4%(27/28),significantly high-er than the control group of 4.0%(1/25)(P<0.05).INSM1 had a sensitivity of 96.4%in MTC,significantly higher than CgA(71.4%)(P<0.05),and was positively expressed in CT negative MTC cases.The specificity of INSM1 in MTC was 96.0%,significantly higher than that of CEA(72.0%)(P<0.05).Conclusion INSM1 has high sensitivity and specificity in MTC,with a nuclear positive staining pattern,clear back-ground,and easy identification.It is superior to the traditional biomarkers and has high diagnostic value in MTC.
