Clinical significance of adhesion G protein-coupled receptor GPR110 in distinguishing acinar and solid lung adenocarcinoma
10.13315/j.cnki.cjcep.2023.11.008
- VernacularTitle:黏附G蛋白偶联受体GPR110辅助诊断腺泡型和实体型肺腺癌的临床意义
- Author:
Chaonan HE
1
;
Keke YU
;
Yongjie NIU
;
Ye ZHANG
Author Information
1. 上海市胸科医院/上海交通大学医学院附属胸科医院生物样本库,上海 200030
- Keywords:
lung neoplasm;
adenocarcinoma;
GPR110;
patholog-ical subtype;
biomarker
- From:
Chinese Journal of Clinical and Experimental Pathology
2023;39(11):1322-1327,1333
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the differential expression of GPR110,an adherent G protein-coupled receptor,and its role in the differential diagnosis of acinar and solid adenocarcinoma of the lung.Methods The expression level of GPR110 was de-termined by immunohistochemistry(IHC),qRT-PCR and ELISA,and ROC and area under the curve(AUC)were ana-lyzed to distinguish the acinar predominant and solid predomi-nant of lung adenocarcinoma,so as to evaluate the role of differ-ential GPR110 expression in the differential diagnosis of these two histopathological subtypes with different prognosis.Results The expression of GPR110 in lung adenocarcinoma tumor tis-sue was significantly higher than that in adjacent tissue,and its expression in solid predominant lung adenocarcinoma was signifi-cantly higher than that in acinar predominant.The average con-centrations of GPR110 protein in 100 pairs of acinar predominant lung adenocarcinoma tumor tissues and its adjacent tissues were 430.53 and 313.26 ng/L by ELISA.The average concentrations of GPR110 protein in 53 pairs of solid predominant lung adeno-carcinoma tumor tissues and its adjacent tissues were 716.56 and 368.46 ng/L,and the differences were statistically signifi-cant(P＜0.001).At the same time,the ROC curve showed that the GPR110 protein had a sensitivity of 77.36％,a speci-ficity of 83.00％,an optimal Cut-off value of 582.27 ng/L,and an AUC of 0.865(0.802-0.927).Conclusion GPR110 has potential application value in the differential diagnosis of acinar type and solid type of adenocarcinoma of the lung,and it is ex-pected to become a new biomarker for differential diagnosis
