Construction and verification of dynamic prognosis graph of gallbladder cancer patients
10.3969/j.issn.1005-6483.2024.02.016
- VernacularTitle:胆囊癌病人预后动态列线图的构建及验证
- Author:
Zhiyang JIANG
1
;
Haile CAN
;
Yafen TANG
;
Xiaogang LI
;
Xiaofeng LIAO
Author Information
1. 430065 武汉科技大学医学院
- Keywords:
gallbladder carcinoma;
prognostic model;
nomograph;
risk factors;
SEER
- From:
Journal of Clinical Surgery
2024;32(2):182-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct a nomogram to predict the prognosis of patients with gallbladder cancer(GBC).Methods The clinicopathological data of GBC patients were extracted from the SEER database,and the independent prognostic factors of GBC patients were analyzed by Cox regression,and a nomogram was constructed.Finally,the column diagrams in the training queue and validation queue are verified.Results Age,T stage,M stage,histological grade,radiotherapy,surgery and tumor size were independent prognostic factors in GBC patients,and the differences were statistically significant(P＜0.05).In the training cohort,the C index was 0.735(95％CI=0.721～0.749),and the AUC values at 1,3 and 5 years were 0.821,0.820 and 0.833,respectively.In the verification group,the C index was 0.733(95％CI=0.711～0.755),and the AUC values for 1,3 and 5 years were 0.816,0.807 and 0.827,respectively.The calibration curve shows that the predicted values of the nomogram are in good agreement with the observed values.The decision curve shows that the nomogram model has better prediction ability than TNM staging system.Conclusion The constructed dynamic prognosis nomogram of GBC patients has high accuracy and reliability.
