Predictive value of urinary exosomal miR-29c in clinical outcomes of organ-and non-organ-confined bladder urothelial carcinoma
10.3969/j.issn.1005-6483.2024.02.009
- VernacularTitle:尿外泌体miR-29c对器官和非器官局限性膀胱尿路上皮癌临床结局的预测价值
- Author:
Zhigang WANG
1
;
Qingchuan DONG
;
Yi SUN
;
Wanli DUAN
;
Zhenfeng GUAN
;
Liang PAN
Author Information
1. 710068 西安,陕西省人民医院泌尿外科
- Keywords:
urinary exosomal miR-29c;
organ-and non-organ-confined bladder urothelial carcinoma;
clinical outcome
- From:
Journal of Clinical Surgery
2024;32(2):148-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of urinary exosomal microRNA(miR)-29 c in the clinical outcome of organ-and non-organ-confined bladder urothelial carcinoma(BUC).Methods From January 2017 to March 2022,152 patients with BUC were recruited from the Department of Urology in our hospital as a validation set.In addition,126 non-cancer controls were selected from the physical examination center of our hospital.The expression level of urinary exosomal miR-29c was detected by real-time quantitative PCR.Results In the validation set,urinary exosomal miR-29c level in BUC patients was significantly lower than that in non-cancer control group(P＜0.05),while urinary exosomal miR-17-5p level and miR-590-5p level were not significantly different(P＞0.05).The area under ROC curve of urinary exosomal miR-29c for the diagnosis of BUC was 0.969(95％CI:0.953～0.986),and the corresponding sensitivity and specificity were 92.1％and 90.2％,respectively.In subtype analysis,urinary exosomal miR-29c levels were further reduced in patients with non-organ-confined BUC compared with patients with organ-confined BUC(P=0.009).Overall survival(OS),disease-free survival(DFS)and disease-specific survival(DSS)were longer in the urinary exosomal miR-29c high expression group(P＜0.05).Conclusion Low levels of urinary exosomal miR-29c are an adverse prognostic factor for survival in patients with BUC,and are promising as a predictor of adverse clinical outcomes of organ-and non-organ-confined BUC.
