Clinical efficacy of immunotherapy combined with chemotherapy sequential surgery for locally advanced esophageal cancer
10.3969/j.issn.1005-6483.2023.11.011
- VernacularTitle:免疫联合化疗序贯手术应用于局部晚期食管癌的临床疗效
- Author:
Xinglin LONG
1
;
Songping XIE
;
Gaoli LIU
;
Wenhan ZHANG
;
Jie HUANG
Author Information
1. 430205 武汉大学人民医院胸外科
- Keywords:
Tislelizumab;
locally advanced esophageal carcinoma;
immune checkpoint inhibitors;
neoadjuvant therapy;
immunotherapy
- From:
Journal of Clinical Surgery
2023;31(11):1040-1043
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the safety and efficiency of sequential operation of Tirelizumab combined with chemotherapy in neoadjuvant therapy for locally advanced esophageal cancer.Methods A retrospective analysis was conducted on 60 patients with locally advanced esophageal cancer admitted to Renmin Hospital of Wuhan University from August 2018 to June 2022.The immunotherapy combined with chemotherapy sequential surgery patients were selected as the observation group(29 cases)and the chemotherapy sequential surgery patients were selected as the control group(31 cases)according to the treatment method.The study aimed to analyze whether there were differences in efficacy and safety between the two groups.Results There are 28 patients with R0 resection in the observation group,and 14 case reached ORR.In the control group,29 cases were resected with R0,and 7 cases reached ORR.The proportion of ORR patients in the observation group was significantly higher than that in the control group,which was statistically significant(P＜0.05).There were 9 patients with pCR in the observation group and 2 patients with pCR in the control group,and the proportion of pCR patients in the two groups was significantly different(P＜0.05).There were no significant differences between the two groups for preoperative and postoperative adverse events.Conclusion Immune checkpoint inhibitors combined with chemotherapy sequential surgery are safe and reliable in patients with locally advanced esophageal cancer,with significant short-term efficacy,and long-term efficacy remains to be observed.
